TransMalariaBloc researchers develop novel vaccine vector

Publication alert!
TransMalariaBloc scientists at Imperial College London report on the development of a novel experimental vaccine vector, the "Baculovirus Dual Expression System", which drives expression of transmission blocking vaccine candidate antigens. Significantly, the system supports intranasal and intramuscular immunization routes, functioning both as a subunit and DNA based vaccine. This study offers a novel tool for the development of malarial transmission-blocking vaccines against the sexual stages of the parasite.

Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission. Blagborough AM, Yoshida S, Sattabongkot J, Tsuboi T, Sinden RE. Vaccine. 2010 Aug 23;28(37):6014-20.

To read the abstract from the August 2010 issue of Vaccine, click here: http://www.ncbi.nlm.nih.gov/pubmed/20637303