Publication alert!
An exciting TransMalariaBloc study from the University of Camerino describes the complete blockage of malaria parasite development in its mosquito vector by treatment with NeemAzal(R), an azadirachtin-enriched extract of neem seeds. Azadirachtin interferes with the microtubule components of the parasite cytoskeleton, which plays fundamental roles in parasite sexual development, a process that is essential for malaria transmission. These results further encourages the future exploration of neem compounds as novel transmission-blocking remedies.
Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi. Lucantoni L, Yerbanga RS, Lupidi G, Pasqualini L, Esposito F, Habluetzel A. Malaria Journal. 2010 Mar 2;9:66.